Key result
Rate versus rhythm control for AF shows equivocal mortality benefits.
Why the study?
Mortality benefits comparing rate versus rhythm control in atrial fibrillation remain equivocal across multiple studies over the past decade.
Does rhythm control compared to rate control improve mortality and quality of life in patients with atrial fibrillation?
Does rhythm control compared to rate control improve mortality and quality of life in patients with atrial fibrillation?
Rate control is a safe and effective strategy for asymptomatic AF patients, while rhythm control is suitable for symptomatic patients, with no clear mortality difference between the two strategies.
Answers are grounded in this paper and cite their sources.
Supports symptom-driven rate or rhythm selection in AF; leaves open need for updated RCTs on mortality with contemporary therapies.
Atrial fibrillation (AF) remains the most common arrhythmia worldwide and is expected to affect approximately 12 million individuals in the United States alone by 2030. Thromboembolic events remain a feared complication of AF and should be treated and risk-stratified utilizing the CHA₂DS₂-VASc scoring system. Other complications of AF span a wide spectrum from impaired quality of life (QoL) to an increase in all-cause mortality. Rate control strategies consist of controlling the ventricular rate and have been shown to be a safe and effective strategy for asymptomatic AF patients. In patients who are plagued with symptoms leading to impaired QoL or a decrease in exercise capacity, rhythm control with antiarrhythmic drugs or catheter ablation may be suitable options. Mortality benefits when comparing rate versus rhythm control remain equivocal when comparing multiple studies over the past decade.
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Vargas et al. (2023) conducted a review in Atrial Fibrillation. Rate control vs. Rhythm control was evaluated on Mortality. Rate versus rhythm control strategies for atrial fibrillation show equivocal mortality benefits based on multiple studies over the past decade.
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