Key result
Persistent AF is linked to ~400% greater odds of low voltage zones versus paroxysmal AF.
Why the study?
What are the prevalence and predictors of low voltage zones in the left atrium in patients undergoing ablation for atrial fibrillation?
Cohort (n=539)
What are the prevalence and predictors of low voltage zones in the left atrium in patients undergoing ablation for atrial fibrillation?
Effect estimate: OR 5.03 (95% CI 3.20-7.90)
Absolute Event Rate: 54.3% vs 19.9%
p-value: p=<0.001
In patients undergoing AF ablation, low voltage zones are more prevalent and larger in persistent AF, and are independently predicted by age, female gender, sinoatrial node dysfunction, and larger left atrial surface area.
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May support LVZ-guided ablation in persistent AF; hypothesis-generating, requires prospective validation.
Huo et al. (2017) conducted a cohort in Paroxysmal and persistent atrial fibrillation (n=539). Persistent atrial fibrillation vs. Paroxysmal atrial fibrillation was evaluated on Presence of low voltage zones (LVZ) (OR 5.03, 95% CI 3.20-7.90, p=<0.001). Persistent atrial fibrillation was associated with a higher prevalence of low voltage zones compared to paroxysmal AF (54.3% vs 19.9%; OR 5.03, 95% CI 3.20-7.90, P<0.001).
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