Given a sample of size n from a distribution P_λ, one wants to estimate a functional ψ(λ) of the (typically infinite-dimensional) parameter λ. Lower bounds on the performance of estimators can be based on the concept of a differentiable functional P_λ → ψ(λ). In this paper we relate a suitable definition of differentiable functional to differentiability of α → dP1/2_λ and λ → ψ(λ). Moreover, we show that regular estimability of a functional implies its differentiability.
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Aad van der Vaart (1991) studied this question.