Key result
Hydrogen sulfide induces vasodilation and regulates vascular tone by activating vascular potassium channels.
Why the study?
H2S plays a key role in vascular homeostasis and vascular diseases, and evidence indicates vascular potassium channel activation is involved in H2S-induced vasodilation.
This review highlights that hydrogen sulfide induces vasodilation primarily through the activation and sulfhydration of vascular potassium channels, presenting a potential therapeutic target for vascular diseases.
Should not yet change vascular disease management; leaves open H2S-K channel targeting as hypothesis-generating for future trials.
Hydrogen sulfide (H 2 S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H 2 S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in H 2 S biogenesis has been reported in a variety of vascular diseases and H 2 S supplementation exerts effects of vasodilation. Accumulating evidence has shown vascular potassium channels activation is involved in H 2 S-induced vasodilation. This review aimed to summarize and discuss the role of H 2 S in the regulation of vascular tone, especially by interaction with different vascular potassium channels and the underlying mechanisms.
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Liu et al. (2022) conducted a review in Vascular diseases. Hydrogen sulfide (H2S) was evaluated. Hydrogen sulfide induces vasodilation and regulates vascular tone by interacting with and activating vascular potassium channels, including KATP, KCa, and KV channels.
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