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Purpose of Review Fungal endocarditis is an uncommon and challenging condition diagnostically and with respect to management. Medical literature on this topic is limited to case series, meta-analysis, review articles, and expert opinion. Recent Findings This brief review aims to describe major themes across the broad array of potential pathogens, but with a focus on nuanced points relating to the most common etiologies. The emphasis of this review will be clinical, focusing on general and species-specific risk factors, epidemiology, diagnosis, and management. Summary The presentation of fungal endocarditis is non-specific and requires a high degree of clinical suspicion to make the diagnosis. Candida, Aspergillus , and Histoplasma are the most common causative agents, and while they share common trends, they have very distinct differences in epidemiology, diagnosis, and management.
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Forrister et al. (2025) studied this question.
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