Key result
Simultaneous LAAC and ASD closure achieves 100% procedural success without major long-term complications.
Why the study?
Patients with AF and ASD face elevated thromboembolic risks, but evidence on combined LAAC and ASD closure remains limited.
Does a 'one-stop' combined percutaneous left atrial appendage and atrial septal defect closure provide a safe and feasible strategy for stroke prevention in patients with non-valvular atrial fibrillation and atrial septal defect?
Cohort (n=40)
No
Does a 'one-stop' combined percutaneous left atrial appendage and atrial septal defect closure provide a safe and feasible strategy for stroke prevention in patients with non-valvular atrial fibrillation and atrial septal defect?
Simultaneous percutaneous LAAC and ASD closure is a technically feasible and safe strategy for stroke prevention in patients with non-valvular AF and ASD.
Answers are grounded in this paper and cite their sources.
Supports combined LAAC-ASD closure feasibility in select AF patients; leaves open need for randomized trials on outcomes.
Background: Patients with atrial fibrillation (AF) and atrial septal defect (ASD) face elevated thromboembolic risks, yet evidence on combined left atrial appendage closure (LAAC) and ASD closure remains limited. We aimed to assess the feasibility and safety of a "one-stop" strategy for simultaneous LAAC and ASD closure. Methods: A retrospective analysis included 40 patients with non-valvular AF and ASD undergoing combined procedures (2016-2024). Procedural success, complications, and long-term outcomes (mean follow-up: 1,194.3 days) were analyzed. Results: All procedures were technically successful. No major complications (stroke, device embolization, or death) occurred during follow-up. Peri-device leak (PDL) was observed in 19 patients (47.5%), with only one case of device-related thrombus (resolved with anticoagulation). Conclusion: The "one-stop" approach is a safe and effective strategy for stroke prevention in AF patients with ASD, particularly those unsuitable for long-term anticoagulation.
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Wang et al. (2025) conducted a cohort in Non-valvular atrial fibrillation and atrial septal defect (n=40). Simultaneous LAAC and ASD closure was evaluated on Procedural success, complications, and long-term outcomes. A "one-stop" strategy for simultaneous LAAC and ASD closure achieved 100% procedural success with no major complications over a mean follow-up of 1,194.3 days.
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