Key result
CYP2C19-guided clopidogrel dosing is advocated to reduce resistance and adverse CV events in Asian populations.
Why the study?
CYP2C19 genetic polymorphism drives high inter-individual variability in clopidogrel outcomes, and its high prevalence in Asian populations warrants precision medicine approaches to optimize dosing and reduce adverse events.
Does a precision medicine approach using pharmacogenetic information optimize clopidogrel dosage and reduce adverse cardiovascular events?
Does a precision medicine approach using pharmacogenetic information optimize clopidogrel dosage and reduce adverse cardiovascular events?
A precision medicine approach utilizing CYP2C19 pharmacogenetic information may help optimize clopidogrel dosing and reduce adverse cardiovascular events, particularly in Asian populations.
May support CYP2C19-guided clopidogrel dosing in Asians; hypothesis-generating pending prospective trials.
Clopidogrel is a prodrug chiefly metabolized by the hepatic isoenzyme CYP2C19 to its active metabolite that inhibits the platelet aggregation. It has been proven in many populations that the genetic polymorphism of CYP2C19 has influence on the pharmacokinetic and or pharmacodynamics of this drug and resulting in high inter-individual variability in the treatment outcomes. As CYP2C19 genetic polymorphism is highly prevalent among the Asian population, the influence of the same on the pharmacokinetics and; thereby, the pharmacodynamics of clopidogrel needs more attention. Using the pharmacogenetic information for drug therapy could help overcome these issues and to optimize the dosage regimen of clopidogrel, this review advocates the precision medicine approach for reducing the clopidogrel resistance and adverse cardiovascular events.
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Aswathy et al. (2022) conducted a review in Clopidogrel resistance and adverse cardiovascular events. Clopidogrel (precision medicine approach) was evaluated. A precision medicine approach using CYP2C19 pharmacogenetic information is advocated to optimize clopidogrel dosage and reduce resistance and adverse cardiovascular events in Asian populations.
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