Key result
AF in HCM is linked to lower serum-native thiol and a more oxidized disulphide/thiol ratio.
Why the study?
The study sought to determine the relationship between the presence of AF and serum biomarkers, including native thiol, disulphide/native thiol ratio, Hs-CRP, and Hs-TnI, in hypertrophic cardiomyopathy.
Does the presence of atrial fibrillation alter serum biomarkers of oxidative stress and inflammation in patients with hypertrophic cardiomyopathy?
Observational (n=161)
Does the presence of atrial fibrillation alter serum biomarkers of oxidative stress and inflammation in patients with hypertrophic cardiomyopathy?
p-value: p=<0.001
Oxidative stress and inflammatory biomarkers are significantly elevated in hypertrophic cardiomyopathy patients with atrial fibrillation compared to those without.
Aim: We sought to determine the relationship between presence of atrial fibrillation (AF) and serum biomarkers, including native thiol (antioxidant), disulphide/native thiol ratio, Hs-CRP and high-sensitivity Troponin-I (Hs-TnI) in hypertrophic cardiomyopathy (HCM). Materials & methods: We enrolled consecutive 121 HCM outpatients without AF and 40 HCM outpatients with AF. A 12-lead electrocardiogram, transthoracic echocardiography and 24/48-h ambulatory rhythm monitoring were performed for all patients. Fasting venous blood samples were taken from all study patients to measure serum thiol-disulphide homeostasis, Hs-CRP and Hs-TnI. Results: Serum-native thiol was lower and disulphide/native thiol ratio was more oxidized in HCM patients with AF (p < 0.001). Also, HCM patients with AF had higher Hs-TnI and Hs-CRP than no-AF HCM patients. Disulphide/native thiol ratio, serum-native thiol, age, NYHA functional class≥III, and advanced diastolic dysfunction were independently associated with the presence of AF in HCM. Conclusion: In addition to clinical and echocardiographic findings, oxidative stress is also associated with AF in HCM patients.
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Sarı et al. (2021) conducted an observational in Hypertrophic cardiomyopathy (n=161). Atrial fibrillation vs. No atrial fibrillation was evaluated on Serum-native thiol and disulphide/native thiol ratio (p=<0.001). Atrial fibrillation in patients with hypertrophic cardiomyopathy was associated with lower serum-native thiol and a more oxidized disulphide/native thiol ratio (p < 0.001).
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