Key result
Permanent pacemaker implantation and verapamil administration resulted in 0 observed premature beats or pause dependent torsade de pointes in a 21-year-old woman with long QT syndrome.
Why the study?
Does permanent pacemaker implantation combined with verapamil prevent torsade de pointes in a patient with long QT syndrome refractory to beta-blockers?
Case Report (n=1)
Does permanent pacemaker implantation combined with verapamil prevent torsade de pointes in a patient with long QT syndrome refractory to beta-blockers?
Permanent pacemaker implantation combined with verapamil may be an effective strategy for preventing pause-dependent torsade de pointes in patients with long QT syndrome who are refractory to standard beta-blocker therapy.
May support pacemaker plus verapamil in refractory LQTS; hypothesis-generating and requires prospective validation before practice change.
A 21-year-old woman with long QT syndrome and missense mutation in HERG (T613M), suffered from repeated attacks of pause dependent torsade de pointes, even though she was given beta-blockers and underwent stellate ganglion block twice at the age of eight. After she received permanent pacemaker implantation and administration of verapamil, no premature beats or pause dependent torsade de pointes was observed.
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Komiya et al. (2004) conducted a case report in Long QT syndrome with pause dependent torsade de pointes (n=1). Permanent pacemaker implantation and verapamil administration was evaluated on Occurrence of premature beats or pause dependent torsade de pointes. Permanent pacemaker implantation and verapamil administration resulted in 0 observed premature beats or pause dependent torsade de pointes in a 21-year-old woman with long QT syndrome.
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