Key result
Cardiovascular long COVID linked to a ~2% incidence of new vasospastic angina via provocation testing.
Why the study?
Diagnosing the cause of chest pain related to post-acute sequelae of COVID-19 is often challenging in patients with a low pre-test probability of CAD.
Is vasospastic angina a potential cause of chest pain in patients with post-acute sequelae of COVID-19?
Case Report (n=273)
No
Is vasospastic angina a potential cause of chest pain in patients with post-acute sequelae of COVID-19?
Vasospastic angina should be considered as a potential cause of chest pain in patients presenting with post-acute sequelae of COVID-19.
Diagnosing the cause of post-acute sequelae of COVID-19 (PASC, also known as long COVID)-related chest pain is often challenging in patients with a low pre-test probability of coronary artery disease. In a retrospective review of 273 consecutive patients who presented to the cardiovascular outpatient unit for cardiovascular PASC at the Hokkaido Cardiovascular Hospital, Japan, 8 patients were suspected to have vasospastic angina (VSA) and underwent acetylcholine provocation testing, 5 of whom (1.8%, 5/273) were newly diagnosed with VSA. Although the causal relationship between VSA and PASC should be studied further, the present study suggests that VSA can be a potential cause of chest pain in patients with PASC.
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Aikawa et al. (2025) conducted a case report in Cardiovascular post-acute sequelae of COVID-19 (PASC) (n=273). Acetylcholine provocation testing was evaluated on Diagnosis of vasospastic angina. Among 273 patients with cardiovascular post-acute sequelae of COVID-19, 5 patients (1.8%) were newly diagnosed with vasospastic angina via acetylcholine provocation testing.
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