Key result
Chronic milrinone therapy after acute myocardial infarction in rats attenuated progressive left ventricular dilation, lowering left ventricular volume (1.25 vs 2.37 ml/kg, p<0.001).
Why the study?
Does milrinone improve left ventricular remodeling after acute myocardial infarction in a rat model?
Population
Rats (n=90) undergoing left coronary artery ligation (acute myocardial infarction model) or sham operation
Comparison
Milrinone started 3 weeks after surgery and… vs No treatment
Design
Preclinical, Randomized
Follow-up
90 days
Authors
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Caution against milrinone for post-MI remodeling in patients; leaves open translation of rat findings to clinical trials.
RCT (n=90)
randomized
Does milrinone improve left ventricular remodeling after acute myocardial infarction in a rat model?
Absolute Event Rate: 1.25% vs 2.37%
p-value: p=<0.001
In a rat model of myocardial infarction, chronic milrinone therapy attenuated progressive left ventricular dilation and improved hemodynamic indices.
Jain et al. (1991) conducted an RCT in acute myocardial infarction (n=90). milrinone vs. no treatment was evaluated on left ventricular volume (ml/kg) (p=<0.001). Chronic milrinone therapy after acute myocardial infarction in rats attenuated progressive left ventricular dilation, lowering left ventricular volume (1.25 vs 2.37 ml/kg, p<0.001).
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