Key result
Prolonged strenuous exercise frequently elevates hs-cTn levels, potentially signaling early cardiovascular risk.
Why the study?
Recent studies suggest exercise-induced increases in hs-cTn values may not always be physiological and could represent an early cardiovascular risk marker.
Does strenuous and prolonged exercise cause physiological or pathological increases in high-sensitivity cardiac troponin levels in healthy adults?
Does strenuous and prolonged exercise cause physiological or pathological increases in high-sensitivity cardiac troponin levels in healthy adults?
This review highlights that elevated high-sensitivity cardiac troponin following strenuous exercise may serve as an early marker of cardiovascular risk rather than a purely benign physiological response.
Answers are grounded in this paper and cite their sources.
May warrant caution in troponin interpretation among athletes; leaves open whether elevations predict events or reflect adaptation.
All the latest international guidelines recommend that cardiac troponin (cTn) I and T should be considered the preferred biomarkers for diagnosis of acute myocardial infarction. However, only in the last 5 years, a progressive improvement in analytical performance of immunometric assays has allowed the measurement of circulating levels of cTnI and cTnT in the large part of apparently healthy adult subjects. The routine use of these high-sensitivity methods for cardiac troponin (hs-cTn) assay has in a short time demonstrated that cardiac troponin concentrations frequently increase after strenuous prolonged exercise in healthy athletes. This acute response of hs-cTn assay following exercise was at first considered to be physiological and without long-term adverse consequences. More recent studies have suggested that exercise-induced increases in hs-cTn values may not be always a physiological response to exercise, but, conversely, it should sometimes be considered as an early cardiovascular risk marker. The aim of this review is to provide an overview of acute and chronic effects of strenuous physical exercise on hs-cTn circulating levels and also to discuss the potential pathophysiological and clinical implications of biomarker responses.
No takes yet. Share an insight, caveat, or question.
Perrone et al. (2020) conducted a review in Strenuous physical exercise. Strenuous physical exercise was evaluated on High-sensitivity cardiac troponin (hs-cTn) levels. Strenuous prolonged exercise frequently induces increases in high-sensitivity cardiac troponin values, which may sometimes serve as an early cardiovascular risk marker.
Synapse has enriched 10 related papers. Consider them for comparative context: