A comprehensive review of cardiac troponin metabolism highlights mechanisms of release, circulation, elimination, and penetration into biological fluids to optimize laboratory diagnostics.
The metabolic processes of endo- and exogenous compounds play an important role in diagnosing and treating patients since many metabolites are laboratory biomarkers and/or targets for therapeutic agents. Cardiac troponins are one of the most critical biomarkers to diagnose cardiovascular diseases, including acute myocardial infarction. The study of troponin metabolism is of great interest as it opens up new possibilities for optimizing laboratory diagnostics. This article discusses in detail the key stages of the cardiac troponins metabolism, in particular the mechanisms of release from a healthy myocardium, mechanisms of circulation in the bloodstream, possible mechanisms of troponin penetration into other biological fluids (oral fluid, cerebrospinal fluid, pericardial and amniotic fluids), mechanisms of elimination of cardiac troponins from the blood, and daily changes in the levels of troponins in the blood. Considering these aspects of cardiac troponin metabolism, attention is focused on the potential value for clinical practice.
Aleksey M. Chaulin (2021) conducted a review in Cardiovascular diseases, including acute myocardial infarction. Cardiac troponins metabolism was evaluated. A comprehensive review of cardiac troponin metabolism highlights mechanisms of release, circulation, elimination, and penetration into biological fluids to optimize laboratory diagnostics.