Key result
Preoperative malnutrition linked to ~21-fold greater perioperative myocardial injury risk in hip fracture patients.
Why the study?
The relationship between preoperative nutritional status and perioperative myocardial injury risk in older hip fracture surgery patients has not been fully clarified.
Does impaired nutritional status predict perioperative myocardial injury in older patients undergoing hip fracture surgery?
Cohort (n=1,291)
No
Does impaired nutritional status predict perioperative myocardial injury in older patients undergoing hip fracture surgery?
Effect estimate: OR 20.93 (95% CI 5.99-73.16)
Absolute Event Rate: 5.58% vs 0.66%
p-value: p=<0.001
Preoperative nutritional screening using the MNA-SF effectively identifies older hip fracture patients at high risk for perioperative myocardial injury and short-term mortality.
Preoperative malnutrition screening identifies older hip fracture patients at elevated myocardial injury risk; leaves open whether optimization reduces events.
The incidence of perioperative myocardial injury (PMI) in older patients undergoing hip fracture surgery remains high, significantly affecting postoperative recovery and mortality. Malnutrition is a known risk factor for cardiovascular complications, but the relationship between preoperative nutritional status and PMI risk in older hip fracture patients has not been fully clarified. This was a prospective cohort study conducted at a single tertiary care center from 2018 to 2021. A total of 1,291 patients aged ≥65 years undergoing hip fracture surgery were enrolled. Patients were stratified based on their Mini Nutritional Assessment-Short Form (MNA-SF) scores into normal nutritional status (NNS) and impaired nutritional status (INS) groups, with the INS group further subdivided into malnourished (MNA-SF ≤7) and at risk of malnutrition (8 ≤ MNA-SF ≤12) categories. Perioperative myocardial injury occurred in 42 patients (3.25%), with a significantly higher incidence in the INS group (5.58%) compared to the NNS group (0.66%). Multivariate logistic regression analysis showed that malnutrition (OR: 20.93, 95% CI: 5.99–73.16, p < 0.001) and risk of malnutrition (OR: 6.55, 95% CI: 2.26–18.98, p < 0.001) were independent predictors of PMI. Malnutrition was also independently associated with increased 30-day postoperative and in-hospital mortality. The MNA-SF is a simple and effective preoperative screening tool for identifying elderly hip fracture patients at high risk for perioperative myocardial injury and short-term mortality.
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Luo et al. (2025) conducted a cohort in Hip fracture (n=1,291). Impaired nutritional status (malnutrition or at risk) vs. Normal nutritional status was evaluated on Perioperative myocardial injury (PMI) (OR 20.93, 95% CI 5.99-73.16, p=<0.001). Preoperative malnutrition predicted perioperative myocardial injury in older hip fracture patients compared to normal nutritional status (5.58% vs 0.66%; OR 20.93; 95% CI 5.99-73.16; p<0.001).
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