Key result
COR-School cohort establishes reference values for peak post-exercise hs-cTnT in youth.
Why the study?
Understanding the role of physical activity in promoting well-being is critical as childhood health is increasingly at risk.
Does physical activity and cardiorespiratory fitness influence peak post-exercise levels of hs-cTnT in healthy children and adolescents?
Cohort (n=700)
Does physical activity and cardiorespiratory fitness influence peak post-exercise levels of hs-cTnT in healthy children and adolescents?
The COR-School project will establish reference values for post-exercise hs-cTnT in healthy youth and investigate the impact of physical activity on cardiometabolic health.
In an era where childhood health is increasingly at risk, understanding the role of physical activity in promoting well-being is critical. The COR-School project investigates the impact of physical activity on cardiometabolic health in over 700 Spanish children and adolescents aged 8 to 16 years. Over three years, the study will conduct three assessments (baseline and two follow-ups) to evaluate peak post-exercise levels of high-sensitivity cardiac troponin T (hs-cTnT), a biomarker for cardiac stress, following a submaximal 20 m shuttle run test. Secondary objectives include examining the influence of maturational status, physical activity, and cardiorespiratory fitness on hs-cTnT. Participants will complete fitness tests, questionnaires on health habits, sleep, and diet, as well as anthropometric and body composition measurements. Blood samples collected at baseline and three hours post-exercise will measure cardiac biomarkers and lipid profiles. Cardiovascular responses will be tracked using heart rate monitors. Normal ranges of hs-cTnT will be determined using data distribution (percentiles or mean ± SD), stratified by age, sex, and maturational stage. Statistical analyses, including repeated measures ANOVA and Pearson correlation, will explore trends across time, sex, developmental stages, and other health-related outcomes. Beyond providing clinical insights by establishing reference values for hs-cTnT in healthy youth after exercise, findings will inform educational policies to promote physical activity in schools, emphasizing its role in improving fitness, health behaviors, and overall development.
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Aixa‐Requena et al. (2024) conducted a cohort in Healthy youth (n=700). Submaximal 20 m shuttle run test was evaluated on Peak post-exercise levels of high-sensitivity cardiac troponin T (hs-cTnT). The COR-School project is a 3-year prospective study of over 700 Spanish youth aged 8 to 16 years designed to evaluate peak post-exercise levels of hs-cTnT and establish reference values.
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