Key result
Increased inorganic phosphate shifted the calcium-force relationship by 0.86+/-0.13 micromol/L in failing myocardium versus 2.01+/-0.22 micromol/L in nonfailing myocardium (P<0.05).
p-value: p=<0.05
Failing human myocardium exhibits altered myofilament calcium responsiveness to changes in the intracellular milieu (pH, phosphate, cAMP, cGMP) compared to nonfailing myocardium.
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Altered phosphate sensitivity in failing myocardium cautions against extrapolating nonfailing data; leaves open myofilament-targeted therapies for HF.
Hajjar et al. (2000) studied Heart failure. In vitro exposure to varying pH, inorganic phosphate, cAMP, PKA, and cGMP vs. Nonfailing myocardium was evaluated on Myofilament calcium contractile activation and calcium-force relationship (p=<0.05). Increased inorganic phosphate shifted the calcium-force relationship by 0.86+/-0.13 micromol/L in failing myocardium versus 2.01+/-0.22 micromol/L in nonfailing myocardium (P<0.05).
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