CD31+/CD42b− MPs and miR-92a demonstrated high diagnostic value for distinguishing acute myocardial infarction, with AUCs of 0.893 and 0.888 respectively, comparable to cTnI (AUC 0.912).
Observational (n=114)
Do circulating endothelial microparticles and miR-92a have diagnostic value in distinguishing acute myocardial infarction from stable coronary artery disease and healthy controls?
Circulating CD31+/CD42b− endothelial microparticles and miR-92a show high diagnostic accuracy for acute myocardial infarction, comparable to cardiac troponin I.
Effect estimate: AUC 0.893 for CD31+/CD42b- MPs, 0.888 for miR-92a, 0.912 for cTnI
Microparticles (MPs) and miRNAs have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. The present study aims to investigate the diagnostic value of endothelial MPs (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocardial infarction (AMI) from those with CAD. Plasma samples from 37 patients with AMI, 42 patients with stable CAD (SCAD), and 35 healthy adults were collected for investigation in the present study. The numbers of CD31+/CD42b− MPs, CD31+/CD42b+ MPs, and CD31−/CD42b− MPs were measured by flow cytometry and the levels of miR-92a and miR-23a were analyzed using reverse transcription-quantitative PCR. Moreover, cardiac troponin I (cTnI) expression was detected by ELISA to serve as a routine diagnostic parameter. The number of CD31+/CD42b− was higher in AMI group than those in SCAD and healthy groups. Besides, the expression of miR-92a was higher in AMI group compared with two other groups. Furthermore, evidence showed that there was a positive correlation between the levels of CD31+/CD42b− MPs and miR-92a. Finally, the receiver operating characteristic (ROC) curve revealed that the area value under the curve of CD31+/CD42b− MPs, miR-92a and cTnI was 0.893, 0.888, and 0.912 respectively. CD31+/CD42b− MPs and miR-92a might have great potential to provide diagnostic value for AMI and could probably regulate the endothelial dysfunction in AMI patients.
Zhang et al. (2017) conducted an observational in Acute myocardial infarction (AMI) and stable coronary artery disease (SCAD) (n=114). Endothelial microparticles (CD31+/CD42b- MPs) and miR-92a vs. Stable CAD patients and healthy adults was evaluated on Diagnostic value (area under the ROC curve) for distinguishing AMI (AUC 0.893 for CD31+/CD42b- MPs, 0.888 for miR-92a, 0.912 for cTnI). CD31+/CD42b− MPs and miR-92a demonstrated high diagnostic value for distinguishing acute myocardial infarction, with AUCs of 0.893 and 0.888 respectively, comparable to cTnI (AUC 0.912).