Extracts and isolated compounds from seedlings of Ailanthus altissima , were assessed for antiplasmodial activity in vitro . Two quassinoids, ailanthone and 6 α ‐tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine‐resistant and chloroquine‐sensitive strains of Plasmodium falciparum in vitro . Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6 α ‐tigloyloxychaparrinone from this species.
No takes yet. Share an insight, caveat, or question.
Okunade et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: