Key result
Epicardium-derived cell (EPDC)-conditioned medium reduced infarct size and improved heart function in a mouse myocardial infarction model by secreting paracrine factors that promote angiogenesis.
Why the study?
Does EPDC-conditioned medium reduce infarct size and improve heart function in a mouse myocardial infarction model?
Does EPDC-conditioned medium reduce infarct size and improve heart function in a mouse myocardial infarction model?
Epicardium-derived cells secrete paracrine factors that promote angiogenesis, reduce infarct size, and improve heart function in mouse models of myocardial infarction, suggesting a potential therapeutic strategy for cardiac protection.
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Preclinical support for EPDC paracrine factors in MI; leaves open translation to human trials.
Zhou et al. (2011) studied Myocardial infarction. EPDC-conditioned medium was evaluated on Infarct size and heart function. Epicardium-derived cell (EPDC)-conditioned medium reduced infarct size and improved heart function in a mouse myocardial infarction model by secreting paracrine factors that promote angiogenesis.
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