Key result
Microtubule-actin filament hybrid nanostructures exhibit motility on both kinesin- and myosin-coated surfaces, moving like microtubules on kinesin and like actin filaments on myosin.
Demonstrates the successful construction of microtubule-actin filament hybrid nanostructures capable of dual transport on kinesin and myosin surfaces.
Hybrid nanostructures enable dual-motor motility in vitro; hypothesis-generating for cytoskeletal engineering with no immediate cardiovascular implications.
Microtubule–actin filament hybrid nanostructures are constructed with the help of biotin and streptavidin binding. The hybrid nanostructure exhibits motility on both kinesin- and myosin-coated surfaces. Trajectory analysis shows that the hybrid nanostructures move like microtubules when on kinesin and like actin filaments when on myosin. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Choi et al. (2011) studied this question. Microtubule-actin filament hybrid nanostructures was evaluated on Motility on kinesin- and myosin-coated surfaces. Microtubule-actin filament hybrid nanostructures exhibit motility on both kinesin- and myosin-coated surfaces, moving like microtubules on kinesin and like actin filaments on myosin.
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