A method for the quantitative assessment of rapid changes in the delivery rate of hormones into the systemic circulation is reported. Plasma hormone levels are examined in relation to the “non-steady-state” disappearance rate measured following an intravenous infusion of the hormone. The insulin delivery rate in response to iv glucose has been measured; a biphasic insulin response has been confirmed; and the amount of insulin entering the systemic circulation in each phase can be examined.
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Turner et al. (1971) studied this question.