Scavenger receptor type B class I (SR-BI), initially identified as a receptor that recognizes low density lipoprotein (LDL), was recently shown to mediate the selective uptake of high density lipoprotein (HDL) cholesteryl esters in liver and steroidogenic tissues. To evaluate effects on atherosclerosis, transgenic mice with liver-specific overexpression of SR-BI (SR-BI Tg mice) have been crossed onto LDL receptor-deficient backgrounds. To induce atherosclerosis in a setting of moderate hypercholesterolemia, heterozygous LDL receptor-deficient mice (LDLR1) were fed a high fat/cholesterol/bile salt diet, and homozygous LDL receptor knock-outs (LDLR0) were fed a high fat/cholesterol diet. LDLR1/SR-BI Tg mice showed decreases in VLDL, LDL, and HDL cholesterol and a significant 80% decrease in mean lesion area in the aortic root compared with LDLR1 mice (female LDLR1 74, 120 μm2 versus LDLR1/SR-BI Tg 12, 667 μm2; male 25, 747 μm2 versus 5, 448 μm2, respectively). LDLR0/SR-BI Tg mice showed decreased LDL and HDL cholesterol but increased VLDL cholesterol and no significant difference in extent of atherosclerosis compared with LDLR0 mice. Combined data analysis showed a strong correlation between atherosclerotic lesion area and the VLDL+LDL cholesterol level but no correlation with HDL level. These studies demonstrate a strong anti-atherogenic potential of hepatic SR-BI overexpression. In mice with marked overexpression of SR-BI, the protective effect appears to be primarily related to the lowering of VLDL and LDL cholesterol levels. Scavenger receptor type B class I (SR-BI), initially identified as a receptor that recognizes low density lipoprotein (LDL), was recently shown to mediate the selective uptake of high density lipoprotein (HDL) cholesteryl esters in liver and steroidogenic tissues. To evaluate effects on atherosclerosis, transgenic mice with liver-specific overexpression of SR-BI (SR-BI Tg mice) have been crossed onto LDL receptor-deficient backgrounds. To induce atherosclerosis in a setting of moderate hypercholesterolemia, heterozygous LDL receptor-deficient mice (LDLR1) were fed a high fat/cholesterol/bile salt diet, and homozygous LDL receptor knock-outs (LDLR0) were fed a high fat/cholesterol diet. LDLR1/SR-BI Tg mice showed decreases in VLDL, LDL, and HDL cholesterol and a significant 80% decrease in mean lesion area in the aortic root compared with LDLR1 mice (female LDLR1 74, 120 μm2 versus LDLR1/SR-BI Tg 12, 667 μm2; male 25, 747 μm2 versus 5, 448 μm2, respectively). LDLR0/SR-BI Tg mice showed decreased LDL and HDL cholesterol but increased VLDL cholesterol and no significant difference in extent of atherosclerosis compared with LDLR0 mice. Combined data analysis showed a strong correlation between atherosclerotic lesion area and the VLDL+LDL cholesterol level but no correlation with HDL level. These studies demonstrate a strong anti-atherogenic potential of hepatic SR-BI overexpression. In mice with marked overexpression of SR-BI, the protective effect appears to be primarily related to the lowering of VLDL and LDL cholesterol levels. scavenger receptor type B class I total cholesterol cholesteryl ester apolipoprotein low density lipoprotein(s) very LDL high density lipoprotein transgenic (mice) LDL receptor knockout mice fast protein chromatography polyacrylamide gel electrophoresis. Scavenger receptor type B class I (SR-BI),1 a member of the CD36 gene family, was recently shown to bind HDL in a specific fashion and to mediate the selective uptake of HDL cholesteryl esters (CE) in cells and tissues (i.e. the uptake of CE from HDL without degradation of HDL protein (1Acton S. Rigotti A. Landschultz K.T. Xu S. Hobbs H.H. Krieger M. Science. 1996; 271: 518-520Crossref PubMed Scopus (1986) Google Scholar, 2Glass C. Pittman R.C. Weinstein D.B. Steinberg D. Proc. Natl. Acad. Sci. U. S. A. 1983; 80: 5435-5439Crossref PubMed Scopus (420) Google Scholar)). SR-BI is highly expressed in liver and steroidogenic tissues, the principal sites of selective uptakein vivo (3Cao G. Garcia C.K. Wyne K.L. Schultz R.A. Parker K.L. Hobbs H.H. J. Biol. Chem. 1997; 272: 33068-33076Abstract PubMed Scopus Google Scholar, J. Biol. Chem. 1996; 271: PubMed Scopus Google Scholar, K.T. Rigotti A. Krieger M. Hobbs H.H. J. 1996; PubMed Scopus Google with decreased of SR-BI as a of gene have increased HDL cholesterol and decreased selective uptake of HDL CE in the liver A. M. J. Krieger M. Proc. Natl. Acad. Sci. U. S. A. 1997; PubMed Scopus Google Scholar, K.L. D. Proc. Natl. Acad. Sci. U. S. A. PubMed Scopus Google of SR-BI in decreased HDL increased selective uptake of HDL CE in the and in cholesterol of cholesterol Rigotti A. Krieger M. 1997; PubMed Scopus Google Scholar, J. Biol. Chem. PubMed Scopus Google of cholesterol SR-BI be related to increased selective uptake of CE in the as as increased of cholesterol between HDL and M. J. Biol. Chem. 1997; 272: PubMed Scopus Google was as a receptor and LDL Krieger M. J. Biol. Chem. PubMed Google with liver-specific overexpression of SR-BI were to have decreases in VLDL and LDL cholesterol and as as HDL and to be to in in to high high cholesterol J. Biol. Chem. PubMed Scopus Google SR-BI Tg mice in were from J. Biol. Chem. PubMed Scopus Google overexpression of SR-BI was analysis J. Biol. Chem. PubMed Scopus Google hepatic SR-BI protein were shown to be compared with J. Biol. Chem. PubMed Scopus Google of the was to evaluate the of hepatic overexpression of SR-BI on the of LDL receptor mice were of the Hobbs H.H. and of the SR-BI was onto the LDL receptor-deficient S. J. J. PubMed Scopus Google and the mice were with high high cholesterol To evaluate lesion in the of a moderate level of hypercholesterolemia, studies were in LDLR1 mice fed a high fat/cholesterol/bile salt and in LDLR0 mice fed a high fat/cholesterol and were in LDLR1/SR-BI transgenic mice and in LDLR0/SR-BI Tg on high high fat/cholesterol/bile salt with LDLR1 LDLR1/SR-BI Tg mice showed significant decreases in total cholesterol HDL and on but no difference in level. compared with LDLR0 LDLR0/SR-BI Tg mice showed decreases in on and high fat/cholesterol/bile salt was no difference of on the high fat/cholesterol diet. the to decrease in LDLR0/SR-BI Tg compared with LDLR0 but of were In Tg mice HDL cholesterol was decreased on were increased in LDLR0/SR-BI Tg mice on and high fat/cholesterol but on the high fat/cholesterol/bile salt of SR-BI Tg mice in fat/cholesterol fat/cholesterol/bile salt expressed as total and HDL cholesterol and cholesterol was HDL cholesterol from data shown as mean mice SR-BI Tg with LDLR0 on a high fat/cholesterol/bile salt in between the and SR-BI Tg on as in a To the in lipoprotein was on the in LDLR1 with and without the SR-BI on the HDL cholesterol were on the of VLDL and LDL cholesterol was the diet, LDL cholesterol was in Tg mice. the high fat/cholesterol diet, VLDL cholesterol was LDL cholesterol was the high fat/cholesterol/bile salt diet, VLDL and LDL cholesterol were decreased in Tg mice compared with LDLR1 but VLDL and LDL were the was expressed in the LDLR0 LDL cholesterol was in Tg mice compared with LDLR0 and to be a in VLDL the high fat/cholesterol diet, VLDL was but LDL cholesterol was decreased in Tg mice compared with the high fat/cholesterol/bile salt diet, VLDL and LDL cholesterol were in Tg mice compared with LDLR0 mice. In SR-BI HDL and LDL cholesterol in LDLR1 and LDLR0 on the of the high fat/cholesterol in LDLR1 LDL was In VLDL cholesterol was increased on high fat/cholesterol but decreased on the high fat/cholesterol/bile salt evaluate in the analysis was on from of the SR-BI in a marked decrease in on LDL receptor-deficient in to in in LDL and VLDL to the effects on LDL and VLDL cholesterol levels. in Tg was decreased in LDL on high fat/cholesterol/bile salt in the was in the was and In the LDLR0 LDL was decreased on and on high fat/cholesterol and high fat/cholesterol/bile salt as a of SR-BI In VLDL was increased on and high fat/cholesterol but decreased on the high fat/cholesterol/bile salt diet. In VLDL and HDL were decreased on the high fat/cholesterol/bile salt on the SR-BI Tg and of of SR-BI Tg mice in on of mice on high and high fat/cholesterol/bile salt were were density density LDL, and HDL from of to of and HDL in and of density and LDL in were onto and with were in principal of the was to evaluate the effects of overexpression on on Science. 1997; PubMed Scopus Google to evaluate the extent of atherosclerosis in mice with moderate LDLR1 mice fed the high fat/cholesterol/bile salt and LDLR0 mice fed the high fat/cholesterol a of LDLR0 on the high fat/cholesterol/bile salt diet. a high fat/cholesterol/bile salt diet, LDLR1/SR-BI Tg showed 80% decrease in mean atherosclerotic lesion area in the aortic root compared with LDLR1 mice the LDLR0/SR-BI Tg showed no significant difference in extent of atherosclerosis compared with LDLR0 mice on the high fat/cholesterol LDLR0/SR-BI Tg were with a high fat/cholesterol/bile salt atherosclerotic lesion area was These that in LDL receptor-deficient mice the SR-BI decreased the area of atherosclerosis on a salt but no effect on a high fat/cholesterol of atherosclerosis in the of SR-BI Tg mice in LDL receptor-deficient backgrounds. a high fat/cholesterol/bile salt was to the LDLR1 and LDLR1/SR-BI Tg mice were and the and were were with and with mean area of from was mean atherosclerosis μm2 LDLR1 versus μm2 LDLR1/SR-BI μm2 μm2, a high fat/cholesterol/bile salt was to LDLR0 and LDLR0/SR-BI Tg mice high fat/cholesterol was to LDLR0 and LDLR0/SR-BI Tg mice mean atherosclerosis μm2 LDLR0 versus μm2 LDLR0/SR-BI μm2 versus μm2, analysis of the data LDLR1 and LDLR0 mice) showed a strong correlation between atherosclerotic lesion area and VLDL LDL cholesterol and male mice J. PubMed Scopus Google mice to have atherosclerosis In was no between the extent of atherosclerosis and HDL cholesterol between VLDL LDL cholesterol and atherosclerosis area and HDL cholesterol and atherosclerosis area shown SR-BI Tg mice in and mice were fed a high fat/cholesterol high fat/cholesterol/bile salt as in the to Tg Tg studies that SR-BI overexpression in a marked decrease in atherosclerosis in LDL receptor-deficient mice fed the high fat/cholesterol/bile salt in LDLR1 and LDLR0 and and no in atherosclerosis in LDLR0 mice fed the high fat/cholesterol These were induce moderate in total cholesterol (i.e. and a lipoprotein to that in atherosclerosis were highly with effects of SR-BI overexpression on of VLDL LDL cholesterol were the diet. SR-BI overexpression HDL of and LDL receptor to be a of atherosclerosis VLDL+LDL cholesterol was decreased on the low in LDLR1 and LDLR0 mice the SR-BI studies that the overexpression of hepatic SR-BI be anti-atherogenic on a effect of SR-BI overexpression was the lowering of LDL cholesterol and and was in J. Biol. Chem. PubMed Scopus Google and LDLR1 on and high fat/cholesterol/bile salt and in LDLR0 on diet. effects on VLDL cholesterol and were VLDL cholesterol was increased on the diet, increased on the high fat/cholesterol diet, and decreased on the high fat/cholesterol/bile salt diet. effects SR-BI been shown to bind LDL Krieger M. J. Biol. Chem. PubMed Google is to LDL uptake and is to that the LDL lowering effects of SR-BI overexpression is related to increased from the of LDL VLDL of SR-BI in selective uptake of CE from VLDL LDL be in lowering the cholesterol of In the in VLDL and that on the high fat/cholesterol have increased VLDL to increased hepatic uptake of effect be the high of the diet. to on the high fat/cholesterol/bile salt is related to the salt the of the high fat/cholesterol/bile salt been effects Science. 1996; 272: PubMed Scopus Google been as to evaluate atherosclerosis in the J. PubMed Scopus Google Scholar, M. and J. Scholar, J. 1997; PubMed Scopus Google Scholar, J. Scopus Google and to evaluate lipoprotein and atherosclerosis in the of decreased of hepatic D. C. J. 1997; PubMed Scopus Google is to that was a correlation of atherosclerotic lesion area and cholesterol of the that effects of the salt on atherosclerosis primarily in the salt in the in of the in salt in VLDL and LDL that in LDLR0 mice on been shown to be to increased VLDL and LDL S. J. J. PubMed Scopus Google and to be overexpression of J. Biol. Chem. PubMed Scopus Google is that SR-BI overexpression in the of SR-BI in the Rigotti A. Krieger M. 1997; PubMed Scopus Google that SR-BI a to to increased of hepatic cholesterol and the decreased of in to the salt that the of atherosclerosis studies in SR-BI Tg mice is effects on VLDL and LDL cholesterol is with atherosclerosis and D. J. 1997; PubMed Scopus Google a high correlation between extent of atherosclerosis and total cholesterol in mice with of In to of HDL cholesteryl ester protein the extent of in have a on atherosclerosis PubMed Scopus Google Scholar, S. 1997; Scholar, C.K. PubMed Scopus Google the of of HDL effects in SR-BI Tg mice is related to the of HDL cholesterol the liver is increased HDL and decreased J. Biol. Chem. PubMed Scopus Google is of the effects of cholesteryl ester protein HDL the of HDL CE the liver Proc. Natl. Acad. Sci. U. S. A. 1996; PubMed Scopus Google transgenic mice have marked overexpression of SR-BI in the liver J. Biol. Chem. PubMed Scopus Google is that moderate overexpression in a of lipoprotein and decreased atherosclerosis that hepatic overexpression of SR-BI have lowering of the lipoprotein VLDL+LDL cholesterol and was on in LDLR1 and LDLR0 mice. of LDL receptor and be with In the of a low diet, hepatic SR-BI overexpression a lowering LDL cholesterol in with Scavenger receptor type B class I (SR-BI),1 a member of the CD36 gene family, was recently shown to bind HDL in a specific fashion and to mediate the selective uptake of HDL cholesteryl esters (CE) in cells and tissues (i.e. the uptake of CE from HDL without degradation of HDL protein (1Acton S. Rigotti A. Landschultz K.T. Xu S. Hobbs H.H. Krieger M. Science. 1996; 271: 518-520Crossref PubMed Scopus (1986) Google Scholar, 2Glass C. Pittman R.C. Weinstein D.B. Steinberg D. Proc. Natl. Acad. Sci. U. S. A. 1983; 80: 5435-5439Crossref PubMed Scopus (420) Google Scholar)). SR-BI is highly expressed in liver and steroidogenic tissues, the principal sites of selective uptakein vivo (3Cao G. Garcia C.K. Wyne K.L. Schultz R.A. Parker K.L. Hobbs H.H. J. Biol. Chem. 1997; 272: 33068-33076Abstract PubMed Scopus Google Scholar, J. Biol. Chem. 1996; 271: PubMed Scopus Google Scholar, K.T. Rigotti A. Krieger M. Hobbs H.H. J. 1996; PubMed Scopus Google with decreased of SR-BI as a of gene have increased HDL cholesterol and decreased selective uptake of HDL CE in the liver A. M. J. Krieger M. Proc. Natl. Acad. Sci. U. S. A. 1997; PubMed Scopus Google Scholar, K.L. D. Proc. Natl. Acad. Sci. U. S. A. PubMed Scopus Google of SR-BI in decreased HDL increased selective uptake of HDL CE in the and in cholesterol of cholesterol Rigotti A. Krieger M. 1997; PubMed Scopus Google Scholar, J. Biol. Chem. PubMed Scopus Google of cholesterol SR-BI be related to increased selective uptake of CE in the as as increased of cholesterol between HDL and M. J. Biol. Chem. 1997; 272: PubMed Scopus Google SR-BI was as a receptor and LDL Krieger M. J. Biol. Chem. PubMed Google with liver-specific overexpression of SR-BI were to have decreases in VLDL and LDL cholesterol and as as HDL and to be to in in to high high cholesterol J. Biol. Chem. PubMed Scopus Google SR-BI Tg mice in were from J. Biol. Chem. PubMed Scopus Google overexpression of SR-BI was analysis J. Biol. Chem. PubMed Scopus Google hepatic SR-BI protein were shown to be compared with J. Biol. Chem. PubMed Scopus Google of the was to evaluate the of hepatic overexpression of SR-BI on the of LDL receptor mice were of the Hobbs H.H. and of the SR-BI was onto the LDL receptor-deficient S. J. J. PubMed Scopus Google and the mice were with high high cholesterol To evaluate lesion in the of a moderate level of hypercholesterolemia, studies were in LDLR1 mice fed a high fat/cholesterol/bile salt and in LDLR0 mice fed a high fat/cholesterol diet. and were in LDLR1/SR-BI transgenic mice and in LDLR0/SR-BI Tg on high high fat/cholesterol/bile salt with LDLR1 LDLR1/SR-BI Tg mice showed significant decreases in total cholesterol HDL and on but no difference in level. compared with LDLR0 LDLR0/SR-BI Tg mice showed decreases in on and high fat/cholesterol/bile salt was no difference of on the high fat/cholesterol diet. the to decrease in LDLR0/SR-BI Tg compared with LDLR0 but of were In Tg mice HDL cholesterol was decreased on were increased in LDLR0/SR-BI Tg mice on and high fat/cholesterol but on the high fat/cholesterol/bile salt of SR-BI Tg mice in fat/cholesterol fat/cholesterol/bile salt expressed as total and HDL cholesterol and cholesterol was HDL cholesterol from data shown as mean mice SR-BI Tg with LDLR0 on a high fat/cholesterol/bile salt in between the and SR-BI Tg on as in a To the in lipoprotein was on the in LDLR1 with and without the SR-BI on the HDL cholesterol were on the of VLDL and LDL cholesterol was the diet, LDL cholesterol was in Tg mice. the high fat/cholesterol diet, VLDL cholesterol was LDL cholesterol was the high fat/cholesterol/bile salt diet, VLDL and LDL cholesterol were decreased in Tg mice compared with LDLR1 but VLDL and LDL were the was expressed in the LDLR0 LDL cholesterol was in Tg mice compared with LDLR0 and to be a in VLDL the high fat/cholesterol diet, VLDL was but LDL cholesterol was decreased in Tg mice compared with the high fat/cholesterol/bile salt diet, VLDL and LDL cholesterol were in Tg mice compared with LDLR0 mice. In SR-BI HDL and LDL cholesterol in LDLR1 and LDLR0 on the of the high fat/cholesterol in LDLR1 LDL was In VLDL cholesterol was increased on high fat/cholesterol but decreased on the high fat/cholesterol/bile salt evaluate in the analysis was on from of the SR-BI in a marked decrease in on LDL receptor-deficient in to in in LDL and VLDL to the effects on LDL and VLDL cholesterol levels. in Tg was decreased in LDL on high fat/cholesterol/bile salt in the was in the was and In the LDLR0 LDL was decreased on and on high fat/cholesterol and high fat/cholesterol/bile salt as a of SR-BI In VLDL was increased on and high fat/cholesterol but decreased on the high fat/cholesterol/bile salt diet. In VLDL and HDL were decreased on the high fat/cholesterol/bile salt on the SR-BI Tg and principal of the was to evaluate the effects of overexpression on on Science. 1997; PubMed Scopus Google to evaluate the extent of atherosclerosis in mice with moderate LDLR1 mice fed the high fat/cholesterol/bile salt and LDLR0 mice fed the high fat/cholesterol a of LDLR0 on the high fat/cholesterol/bile salt diet. a high fat/cholesterol/bile salt diet, LDLR1/SR-BI Tg showed 80% decrease in mean atherosclerotic lesion area in the aortic root compared with LDLR1 mice the LDLR0/SR-BI Tg showed no significant difference in extent of atherosclerosis compared with LDLR0 mice on the high fat/cholesterol LDLR0/SR-BI Tg were with a high fat/cholesterol/bile salt atherosclerotic lesion area was These that in LDL receptor-deficient mice the SR-BI decreased the area of atherosclerosis on a salt but no effect on a high fat/cholesterol of atherosclerosis in the of SR-BI Tg mice in LDL receptor-deficient backgrounds. a high fat/cholesterol/bile salt was to the LDLR1 and LDLR1/SR-BI Tg mice were and the and were were with and with mean area of from was mean atherosclerosis μm2 LDLR1 versus μm2 LDLR1/SR-BI μm2 μm2, a high fat/cholesterol/bile salt was to LDLR0 and LDLR0/SR-BI Tg mice high fat/cholesterol was to LDLR0 and LDLR0/SR-BI Tg mice mean atherosclerosis μm2 LDLR0 versus μm2 LDLR0/SR-BI μm2 versus μm2, analysis of the data LDLR1 and LDLR0 mice) showed a strong correlation between atherosclerotic lesion area and VLDL LDL cholesterol and male mice J. PubMed Scopus Google mice to have atherosclerosis In was no between the extent of atherosclerosis and HDL cholesterol between VLDL LDL cholesterol and atherosclerosis area and HDL cholesterol and atherosclerosis area shown SR-BI Tg mice in and mice were fed a high fat/cholesterol high fat/cholesterol/bile salt as in the to Tg Tg and were in LDLR1/SR-BI transgenic mice and in LDLR0/SR-BI Tg on high high fat/cholesterol/bile salt with LDLR1 LDLR1/SR-BI Tg mice showed significant decreases in total cholesterol HDL and on but no difference in level. compared with LDLR0 LDLR0/SR-BI Tg mice showed decreases in on and high fat/cholesterol/bile salt was no difference of on the high fat/cholesterol diet. the to decrease in LDLR0/SR-BI Tg compared with LDLR0 but of were In Tg mice HDL cholesterol was decreased on were increased in LDLR0/SR-BI Tg mice on and high fat/cholesterol but on the high fat/cholesterol/bile salt diet. expressed as total and HDL cholesterol and cholesterol was HDL cholesterol from data shown as mean mice SR-BI Tg with LDLR0 on a high fat/cholesterol/bile salt in between the and SR-BI Tg on as To the in lipoprotein was on the in LDLR1 with and without the SR-BI on the HDL cholesterol were on the of VLDL and LDL cholesterol was the diet, LDL cholesterol was in Tg mice. the high fat/cholesterol diet, VLDL cholesterol was LDL cholesterol was the high fat/cholesterol/bile salt diet, VLDL and LDL cholesterol were decreased in Tg mice compared with LDLR1 mice. but VLDL and LDL were the was expressed in the LDLR0 LDL cholesterol was in Tg mice compared with LDLR0 and to be a in VLDL the high fat/cholesterol diet, VLDL was but LDL cholesterol was decreased in Tg mice compared with the high fat/cholesterol/bile salt diet, VLDL and LDL cholesterol were in Tg mice compared with LDLR0 mice. In SR-BI HDL and LDL cholesterol in LDLR1 and LDLR0 on the of the high fat/cholesterol in LDLR1 LDL was In VLDL cholesterol was increased on high fat/cholesterol but decreased on the high fat/cholesterol/bile salt diet. To evaluate in the analysis was on from of the SR-BI in a marked decrease in on LDL receptor-deficient in to in in LDL and VLDL to the effects on LDL and VLDL cholesterol levels. in Tg was decreased in LDL on high fat/cholesterol/bile salt in the was in the was and In the LDLR0 LDL was decreased on and on high fat/cholesterol and high fat/cholesterol/bile salt as a of SR-BI In VLDL was increased on and high fat/cholesterol but decreased on the high fat/cholesterol/bile salt diet. In VLDL and HDL were decreased on the high fat/cholesterol/bile salt on the SR-BI Tg and principal of the was to evaluate the effects of overexpression on on Science. 1997; PubMed Scopus Google to evaluate the extent of atherosclerosis in mice with moderate LDLR1 mice fed the high fat/cholesterol/bile salt and LDLR0 mice fed the high fat/cholesterol a of LDLR0 on the high fat/cholesterol/bile salt diet. a high fat/cholesterol/bile salt diet, LDLR1/SR-BI Tg showed 80% decrease in mean atherosclerotic lesion area in the aortic root compared with LDLR1 mice the LDLR0/SR-BI Tg showed no significant difference in extent of atherosclerosis compared with LDLR0 mice on the high fat/cholesterol LDLR0/SR-BI Tg were with a high fat/cholesterol/bile salt atherosclerotic lesion area was These that in LDL receptor-deficient mice the SR-BI decreased the area of atherosclerosis on a salt but no effect on a high fat/cholesterol diet. analysis of the data LDLR1 and LDLR0 mice) showed a strong correlation between atherosclerotic lesion area and VLDL LDL cholesterol and male mice J. PubMed Scopus Google mice to have atherosclerosis In was no between the extent of atherosclerosis and HDL cholesterol studies that SR-BI overexpression in a marked decrease in atherosclerosis in LDL receptor-deficient mice fed the high fat/cholesterol/bile salt in LDLR1 and LDLR0 and and no in atherosclerosis in LDLR0 mice fed the high fat/cholesterol These were induce moderate in total cholesterol (i.e. and a lipoprotein to that in atherosclerosis were highly with effects of SR-BI overexpression on of VLDL LDL cholesterol were the diet. SR-BI overexpression HDL of and LDL receptor to be a of atherosclerosis VLDL+LDL cholesterol was decreased on the low in LDLR1 and LDLR0 mice the SR-BI studies that the overexpression of hepatic SR-BI be anti-atherogenic on a effect of SR-BI overexpression was the lowering of LDL cholesterol and and was in J. Biol. Chem. PubMed Scopus Google and LDLR1 on and high fat/cholesterol/bile salt and in LDLR0 on diet. effects on VLDL cholesterol and were VLDL cholesterol was increased on the diet, increased on the high fat/cholesterol diet, and decreased on the high fat/cholesterol/bile salt diet. effects SR-BI been shown to bind LDL Krieger M. J. Biol. Chem. PubMed Google is to LDL uptake and is to that the LDL lowering effects of SR-BI overexpression is related to increased from the of LDL VLDL of SR-BI in selective uptake of CE from VLDL LDL be in lowering the cholesterol of In the in VLDL and that on the high fat/cholesterol have increased VLDL to increased hepatic uptake of effect be the high of the diet. to on the high fat/cholesterol/bile salt is related to the salt the of the high fat/cholesterol/bile salt been effects Science. 1996; 272: PubMed Scopus Google been as to evaluate atherosclerosis in the J. PubMed Scopus Google Scholar, M. and J. Scholar, J. 1997; PubMed Scopus Google Scholar, J. Scopus Google and to evaluate lipoprotein and atherosclerosis in the of decreased of hepatic D. C. J. 1997; PubMed Scopus Google is to that was a correlation of atherosclerotic lesion area and cholesterol of the that effects of the salt on atherosclerosis primarily in the salt in the in of the in salt in VLDL and LDL that in LDLR0 mice on been shown to be to increased VLDL and LDL S. J. J. PubMed Scopus Google and to be overexpression of J. Biol. Chem. PubMed Scopus Google is that SR-BI overexpression in the of SR-BI in the Rigotti A. Krieger M. 1997; PubMed Scopus Google that SR-BI a to to increased of hepatic cholesterol and the decreased of in to the salt that the of atherosclerosis studies in SR-BI Tg mice is effects on VLDL and LDL cholesterol is with atherosclerosis and D. J. 1997; PubMed Scopus Google a high correlation between extent of atherosclerosis and total cholesterol in mice with of In to of HDL cholesteryl ester protein the extent of in have a on atherosclerosis PubMed Scopus Google Scholar, S. 1997; Scholar, C.K. PubMed Scopus Google the of of HDL effects in SR-BI Tg mice is related to the of HDL cholesterol the liver is increased HDL and decreased J. Biol. Chem. PubMed Scopus Google is of the effects of cholesteryl ester protein HDL the of HDL CE the liver Proc. Natl. Acad. Sci. U. S. A. 1996; PubMed Scopus Google transgenic mice have marked overexpression of SR-BI in the liver J. Biol. Chem. PubMed Scopus Google is that moderate overexpression in a of lipoprotein and decreased atherosclerosis that hepatic overexpression of SR-BI have lowering of the lipoprotein VLDL+LDL cholesterol and was on in LDLR1 and LDLR0 mice. of LDL receptor and be with In the of a low diet, hepatic SR-BI overexpression a lowering LDL cholesterol in with These studies that SR-BI overexpression in a marked decrease in atherosclerosis in LDL receptor-deficient mice fed the high fat/cholesterol/bile salt in LDLR1 and LDLR0 and and no in atherosclerosis in LDLR0 mice fed the high fat/cholesterol These were induce moderate in total cholesterol (i.e. and a lipoprotein to that in atherosclerosis were highly with effects of SR-BI overexpression on of VLDL LDL cholesterol were the diet. SR-BI overexpression HDL of and LDL receptor to be a of atherosclerosis VLDL+LDL cholesterol was decreased on the low in LDLR1 and LDLR0 mice the SR-BI studies that the overexpression of hepatic SR-BI be anti-atherogenic on a diet. effect of SR-BI overexpression was the lowering of LDL cholesterol and and was in J. Biol. Chem. PubMed Scopus Google and LDLR1 on and high fat/cholesterol/bile salt and in LDLR0 on diet. effects on VLDL cholesterol and were VLDL cholesterol was increased on the diet, increased on the high fat/cholesterol diet, and decreased on the high fat/cholesterol/bile salt diet. effects SR-BI been shown to bind LDL Krieger M. J. Biol. Chem. PubMed Google is to LDL uptake and is to that the LDL lowering effects of SR-BI overexpression is related to increased from the of LDL VLDL of SR-BI in selective uptake of CE from VLDL LDL be in lowering the cholesterol of In the in VLDL and that on the high fat/cholesterol have increased VLDL to increased hepatic uptake of effect be the high of the diet. to on the high fat/cholesterol/bile salt is related to the salt the of the high fat/cholesterol/bile salt been effects Science. 1996; 272: PubMed Scopus Google been as to evaluate atherosclerosis in the J. PubMed Scopus Google Scholar, M. and J. Scholar, J. 1997; PubMed Scopus Google Scholar, J. Scopus Google and to evaluate lipoprotein and atherosclerosis in the of decreased of hepatic D. C. J. 1997; PubMed Scopus Google is to that was a correlation of atherosclerotic lesion area and cholesterol of the that effects of the salt on atherosclerosis primarily in the salt in the in of the in salt in VLDL and LDL that in LDLR0 mice on been shown to be to increased VLDL and LDL S. J. J. PubMed Scopus Google and to be overexpression of J. Biol. Chem. PubMed Scopus Google is that SR-BI overexpression in the of SR-BI in the Rigotti A. Krieger M. 1997; PubMed Scopus Google that SR-BI a to to increased of hepatic cholesterol and the decreased of in to the salt diet. that the of atherosclerosis studies in SR-BI Tg mice is effects on VLDL and LDL cholesterol is with atherosclerosis and D. J. 1997; PubMed Scopus Google a high correlation between extent of atherosclerosis and total cholesterol in mice with of In to of HDL cholesteryl ester protein the extent of in have a on atherosclerosis PubMed Scopus Google Scholar, S. 1997; Scholar, C.K. PubMed Scopus Google the of of HDL effects in SR-BI Tg mice is related to the of HDL cholesterol the liver is increased HDL and decreased J. Biol. Chem. PubMed Scopus Google is of the effects of cholesteryl ester protein HDL the of HDL CE the liver Proc. Natl. Acad. Sci. U. S. A. 1996; PubMed Scopus Google transgenic mice have marked overexpression of SR-BI in the liver J. Biol. Chem. PubMed Scopus Google is that moderate overexpression in a of lipoprotein and decreased atherosclerosis that hepatic overexpression of SR-BI have lowering of the lipoprotein VLDL+LDL cholesterol and was on in LDLR1 and LDLR0 mice. of LDL receptor and be with In the of a low diet, hepatic SR-BI overexpression a lowering LDL cholesterol in with the of
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