Key result
In T2D, pulse pressure links non-linearly to CV hospitalization, with lowest risk at ~61 mmHg.
Why the study?
Is pulse pressure associated with the risk of hospitalization for cardiovascular events in people with Type 2 diabetes?
Case-Control (n=3,508)
Yes
Is pulse pressure associated with the risk of hospitalization for cardiovascular events in people with Type 2 diabetes?
In patients with Type 2 diabetes, pulse pressure has a non-linear relationship with cardiovascular hospitalization, with the lowest risk observed at a pulse pressure of 57-63 mmHg.
Pulse pressure may inform risk stratification in type 2 diabetes but should not yet change practice; leaves open optimal targets for prospective trials.
AIM: To investigate the association between pulse pressure and risk of hospitalization for cardiovascular events among people with Type 2 diabetes. METHODS: A population-based case-control study was carried out using data from medical databases. A total of 588 people with Type 2 diabetes from 18 general practices in Cambridgeshire recorded a first hospitalization for a cardiovascular event between 2009 and 2011, and a total of 2920 age-matched, gender-matched and practice-matched control subjects with Type 2 diabetes were selected based on risk-set sampling. Pulse pressure was assessed before admission in 2008-2009. Further dose-response relationships between pulse pressure and risks were explored using spline models. RESULTS: There was a non-linear relationship between pulse pressure and the risk of hospitalization for a cardiovascular event (P < 0.001 for linearity test). The pulse pressure associated with the lowest risk of hospitalization for a cardiovascular event was 61 (95% CI 57-63) mmHg. CONCLUSION: In people with Type 2 diabetes, pulse pressure is a good predictor of risk of hospitalization for cardiovascular events. The risk is lowest with a pulse pressure of 57-63 mmHg.
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Yu et al. (2015) conducted a case-control in Type 2 diabetes (n=3,508). Pulse pressure was evaluated on Hospitalization for a cardiovascular event (p=<0.001). In people with Type 2 diabetes, pulse pressure had a non-linear relationship with the risk of hospitalization for cardiovascular events (P<0.001), with the lowest risk at 61 (95% CI 57-63) mmHg.
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