Answers are grounded in this paper and cite their sources.
A short, highly convergent total synthesis of racemic isostrychnine, and thus strychnine, has been completed. The route involves 14 steps in the longest linear sequence and is highlighted by a cobalt-mediated [2 + 2 + 2]cycloaddition of an alkynylindole nucleus to acetylene.
No takes yet. Share an insight, caveat, or question.
Eichberg et al. (2000) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: