Consensus versus Outcome-based Definitions of Acute-on-chronic Liver Failure: Implications for Risk Stratification and Case Identification

Nipun Verma; Tingting Qi; Pratibha Garg; Arun Valsan; Gowripriya Nair; Julian Pohl; Arathi Venu; Xianbo Wang; Xin Zheng; Guohong Deng; Yan Huang; 孟忠吉; Yanhang Gao; Zhiping Qian; Xiaobo Lu; Feng Liu; Yu Shi; Shang Jia; Yubao Zheng; Yingli He; Meiqian Hu; Changze Hong; Sina Jameie‐Oskooei; R MOOKERJEE; Mohammad Mahdi Saeidinejad; Sunil Taneja; Jinjun Chen; Hai Li; Ajay Duseja; Cornelius Engelmann; Rajiv Jalan

doi:10.14218/jcth.2026.00267

Key Points

This study aims to evaluate the effectiveness of consensus definitions versus outcome-based classifications for acute-on-chronic liver failure.
Comparison of consensus organ failure criteria and A-TANGO classification.
Analysis of clinical validity of both frameworks for risk stratification.
Identification of implications for case identification in ACLF.
Consensus criteria showed a significantly different risk stratification compared to A-TANGO classification.
Clinical validity of the A-TANGO classification was higher in predicting patient outcomes.
Findings suggest the need for uniform definitions for effective management of ACLF.

Implication

Compares consensus organ failure criteria with outcome-calibrated A-TANGO classification for ACLF implications.

Abstract

Acute-on-chronic liver failure (ACLF) lacks a universally accepted definition, and recent efforts have proposed consensus organ failure criteria. In this study, we aimed to compare the clinical validity of a recently proposed consensus ACLF framework with the outcome-calibrated A-TANGO classification.

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Cite This Study

Verma et al. (2026) studied this question.

synapsesocial.com/papers/6a095a877880e6d24efe07f7 https://doi.org/10.14218/jcth.2026.00267

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Consensus versus Outcome-based Definitions of Acute-on-chronic Liver Failure: Implications for Risk Stratification and Case Identification

Key Points

Implication

Abstract

Discussion

Cite This Study

Consensus versus Outcome-based Definitions of Acute-on-chronic Liver Failure: Implications for Risk Stratification and Case Identification

Key Points

Implication

Abstract

Discussion

Cite This Study

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