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May 1, 2026Ophthalmology ScienceOpen Access

A Framework for Standardized Manual Segmentation and Measurement of Uveal Melanoma on Ultrasound

William F. Chadwick Sanjay Ganesh ALBERT DADZIE Yagnesh Lokesh Reem AlAhmadi Xincheng Yao Michael J. Heiferman

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Key Points

The study aims to develop a standardized protocol for segmenting choroidal tumors on ultrasound to enhance measurement consistency in uveal melanoma.
Cross-sectional reproducibility design with 275 ultrasound images from a tertiary ocular oncology clinic.
Two independent reviewers utilized a consensus-based annotation workflow for manual segmentation.
Inter- and intrareviewer agreement assessed using surface-based metrics such as ASSD and HD95.
High average inter-reviewer agreement was achieved with ASSD: 0.14 mm and HD95: 0.49 mm.
Mean absolute errors of 0.21 mm for thickness, 0.59 mm for 1-chord LBD, and 0.72 mm for arclength LBD were observed.
Most discrepancies occurred at the scleral interface and with imaging artifacts.

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Implication

Cross-sectional study validates a manual segmentation protocol to enhance tumor measurement reproducibility in ocular oncology.

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Cite This Study

Chadwick et al. (2026) studied this question.

synapsesocial.com/papers/6a095ac47880e6d24efe09f2 https://doi.org/10.1016/j.xops.2026.101229

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