Evaluates neuroprotective effects of Agaricus bisporus in MPTP-induced Parkinson's disease, suggesting potential therapeutic benefits.
BACKGROUND: Agaricus bisporus contains bioactive proteins, including tyrosinase, which may influence dopaminergic metabolism. Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons driven by oxidative stress, neuroinflammation, and apoptosis. OBJECTIVE: To evaluate the neuroprotective effects of an Agaricus bisporus protein extract (ABE) and its mechanistic basis in an MPTP-induced mouse model of PD. METHODS: A tyrosinase-enriched protein fraction was isolated and administered orally to MPTP-treated mice for 20 days. Behavioral performance, dopaminergic markers, oxidative stress parameters, inflammatory mediators, and apoptosis-related proteins were assessed in the substantia nigra. CONCLUSION: ABE exerts neuroprotective effects in MPTP-induced PD via tyrosinase-associated enhancement of dopaminergic metabolism, alongside antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
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Zhgenti et al. (2026) studied this question.
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