In this study, the synthesis of novel hybrid molecules derived from quinazoline and 1,2,3-triazoles was reported via copper-catalyzed click reaction. The reaction of quinazoline-4-one-2-thione and quinazoline-2,4-dione with 3-bromoprop-1-yne produced mono- and di- prop-2-yn-1-yl substituted quinazoline derivatives. The click reaction of alkyne-functionalized quinazoline derivatives with various aryl azides, using a mixture of EtOH/DMF as an effective solvent, in the presence of copper(II) acetate and sodium ascorbate as catalysts, produced the desired hybrid molecules, mono- and bis-1,2,3-triazole-based quinazoline scaffolds, in good to high yields. The antibacterial properties of these compounds were evaluated using the CLSI standard and the Broth microdilution method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determinations suggest that these compounds hold potential for future research in antibiotic development.
Hashemipour et al. (Fri,) studied this question.