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May 17, 2026Results in ChemistryOpen Access

Hybrid molecules derived from quinazoline and 1,2,3-triazoles: synthesis and antibacterial activity evaluation

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Randomized trial evaluates antibacterial properties in novel quinazoline-triazole hybrids, highlighting potential for antibiotic development.

The aim is to synthesize and evaluate hybrid molecules derived from quinazoline and 1,2,3-triazoles for antibacterial activity.
Synthesis via copper-catalyzed click reaction with quinazoline derivatives and aryl azides.
Evaluation of antibacterial properties using CLSI standards and Broth microdilution method.
Determinations of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC).
Compounds displayed good to high yields in the formation of hybrid structures.
MIC and MBC results suggest significant antibacterial efficacy, indicating their potential as antibiotic candidates.

Hashemipour et al. (2026) studied this question.

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Randomized trial evaluates antibacterial properties in novel quinazoline-triazole hybrids, highlighting potential for antibiotic development.