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May 17, 2026Organic Letters

gem -Difluoroallylation of Unactivated Alkanes Enabled by Core-Fluorinated Acridine d-HAT Catalysis

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Authors

CXChunhua XuNanjing Forestry UniversityZZZhijie ZhangNanjing Forestry UniversityYKYuan KongNanjing Forestry University

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Implication

Reveals a metal-free method for gem-difluoroallylation of unactivated alkanes using acridine, indicating a new approach for catalysis.

Key Points

  • The aim is to develop a metal-free method for the gem-difluoroallylation of unactivated alkanes using core-fluorinated acridine.
  • Evaluated different acridine-core substitutions for optimal reactivity.
  • Performed catalytic reactions under mild conditions with a variety of substrates.
  • Conducted mechanistic studies to understand the reaction pathway.
  • Identified 2-fluoro substitution on acridine as optimal, enhancing reactivity.
  • Successfully transformed unactivated alkanes into gem-difluoroalkenes across a broad substrate range.
  • Mechanistic analysis indicates a radical pathway involving hydrogen atom transfer.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a095b1b7880e6d24efe0e1ahttps://doi.org/10.1021/acs.orglett.6c01553
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