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May 17, 2026PLoS ONE0 citationsOpen Access

Functions of Uninflatable in Drosophila Melanogaster Wing and Notum

Functions of Uninflatable in the Drosophila melanogaster wing and notum

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Authors

TZTaylor ZhangJJJuliet E. JonesLYLaura J. Yee

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Overview

Randomized trial demonstrates Uif's roles in growth and cell fate in Drosophila, highlighting key interactions.

Key Points

  • This research investigates the roles of the uninflatable gene (uif) in the growth and differentiation of Drosophila wing and notum tissues.
  • Utilized previously characterized Gal4 lines and RNAi constructs to suppress uif and Notch expression in different wing compartments.
  • Assessed growth in mitotically derived tissues, cell fate decisions, and Notch-dependent processes.
  • Identified Uif's role in mitotic growth and regulation of pigment synthesis in wing cuticle.
  • Uif controls chemosensory sense organ number via an apoptosis-related mechanism.
  • Loss of uif disrupts growth of notal microchaete sense organ bristles, but does not affect their differentiation.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a095b1b7880e6d24efe0e6ehttps://doi.org/10.1371/journal.pone.0344871
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