Key result
In obese male patients, T2DM with CHD was associated with significantly altered inflammatory mediators compared to those without CHD, including a negative correlation between adiponectin and E-selectin (P=0.0001).
Cross-Sectional (n=70)
p-value: p=0.01
Inflammatory mediators and adipokines are significantly altered in obese T2DM patients with CHD, suggesting that adipose tissue dysfunction contributes to CHD pathogenesis in this population.
No immediate clinical implications for obese T2DM men; leaves open adipokine roles in CHD and needs prospective validation.
Adipose tissue can release proinflammatory mediators, namely C-reactive protein (CRP), interleukin 1β (IL-1β), and monocyte chemotactic protein 1 (MCP-1), contributing to vascular injury and insulin resistance (IR). Other mediators namely, adiponectin and nitric oxide (NO) are protective. We enrolled type 2 diabetes mellitus (T2DM) obese male patients without coronary heart disease ([CHD] group II, n = 25) and T2DM obese patients with CHD (group III, n = 25). They were compared with 20 age- and body mass index (BMI)-matched nondiabetic control males (group I). Fasting blood glucose (FBG), glycated hemoglobin (HbA(1c)%), lipids, insulin, malondialdehyde ([MDA]; lipid peroxidation product), NO, high-sensitivity CRP (hsCRP), IL-1β, MCP-1, adiponectin as well as sE-selectin concentration were significantly different in patients with T2DM and CHD compared with patients without CHD and nondiabetic controls (P = .01). There was a significant negative correlation between adiponectin and E-selectin (P = .0001). Adipose tissue in T2DM obese patients may contribute to the pathogenesis of CHD.
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El‐Mesallamy et al. (2011) conducted a cross-sectional in Type 2 diabetes mellitus, obesity, coronary heart disease (n=70). Type 2 diabetes mellitus with coronary heart disease vs. Type 2 diabetes mellitus without coronary heart disease and nondiabetic controls was evaluated on Concentrations of FBG, HbA1c, lipids, insulin, MDA, NO, hsCRP, IL-1β, MCP-1, adiponectin, and sE-selectin (p=0.01). In obese male patients, T2DM with CHD was associated with significantly altered inflammatory mediators compared to those without CHD, including a negative correlation between adiponectin and E-selectin (P=0.0001).
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