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Objective: Spinal cord injury (SCI) disrupts nerve axons with devastating neurological consequences.However, there is no effective clinical treatment.The purpose of this study was to investigate the effects of the anti-inflammatory, antioxidative, and neuroprotective characteristics of alverine on traumatic spinal injury in a rat model.Materials and Methods: A total of 36 Wistar albino rats, each weighing 300-400 g, were divided into four treatment groups.In Group 1 (sham/control, n=9), only laminectomy was performed.In Group 2 (SCI, n=9), SCI was simulated after laminectomy.In Group 3 (SCI + saline, n=9), physiological saline solution was injected after SCI was induced.In Group 4 (SCI + aloperine), aloperine was administered after SCI was induced.SCI was established using the weight drop technique after laminectomy.Results: Neurological examination scores were significantly better in the aloperine-treated group than in Groups 2 and 3. SCI significantly increased serum and spinal cord tissue glutathione peroxidase, total oxidant status, 8-hydroxiguanosine, and interleukin-6 levels.These levels were successfully reduced with alverine administration.Interleukin-10 and total antioxidant status levels also decreased with alverine administration.Increased histopathological spinal cord damage score and apoptotic index in Groups 2 and 3 were significantly decreased in Group 4. Conclusion: Aloperine reduced apoptosis and increased anti-inflammatory and antioxidative mediator levels, which protected the SCI rat model against secondary nerve injury.
Sönmez et al. (Mon,) studied this question.