The endothelial activation and stress index (EASIX) demonstrated high predictive value for identifying cardiorenal syndrome in patients with chronic kidney disease (AUC 0.821; 95% CI 0.767-0.876).
Observational (n=253)
No
Does the endothelial activation and stress index (EASIX) predict the presence of cardiorenal syndrome in patients with chronic kidney disease?
EASIX demonstrates high predictive value for identifying cardiorenal syndrome in patients with chronic kidney disease.
Effect estimate: AUC 0.821 (95% CI 0.767-0.876)
p-value: p=<.05
This study aimed to investigate predictive value of endothelial activation and the endothelial activation and stress index (EASIX) for chronic kidney disease (CKD) patients with cardiorenal syndrome (CRS). A retrospective study was conducted on 253 CKD patients admitted to our hospital from January 2021 to June 2024. Patients were divided into CRS group (n = 77) and non-CRS group (n = 176). Univariate and binary Logistics regression analyses were performed to identify influencing factors. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of EASIX for CKD patients with CRS. There were significant differences in terms of hypertension, red blood cell count, red cell distribution width (RDW), blood urea nitrogen, albumin, interleukin-6, C-reactive protein, EASIX, and CKD stage between the 2 groups ( P 3.18, with significant differences ( P < .05). EASIX demonstrates high predictive value in predicting CKD patients with CRS, suggesting its inclusion as an evaluation index.
Zhao et al. (2026) conducted an observational in Chronic kidney disease (CKD) with cardiorenal syndrome (CRS) (n=253). Endothelial activation and stress index (EASIX) was evaluated on Predictive value of EASIX for CRS in CKD patients (AUC 0.821, 95% CI 0.767-0.876, p=<.05). The endothelial activation and stress index (EASIX) demonstrated high predictive value for identifying cardiorenal syndrome in patients with chronic kidney disease (AUC 0.821; 95% CI 0.767-0.876).