Application of various ylides in the [4+1] cycloaddition of enaminothiones and N-thioacylformamidines for constructing substituted thiophenes and thiazoles

Yuhang Sun; 王俊傑; Jiangwei Wen; Xiaowen Qu; Daoshan Yang; Kelu Yan

doi:10.1039/d6nj01052k

January 1, 2026New Journal of Chemistry

Application of various ylides in the [4+1] cycloaddition of enaminothiones and N-thioacylformamidines for constructing substituted thiophenes and thiazoles

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Key Points

This research aims to develop a cycloaddition method using ylides to synthesize substituted thiophenes and thiazoles.
Developed cycloaddition of enaminothiones and N-thioacylformamidines with various ylides.
Synthesized products achieved yields between 61% and 84%.
Successfully constructed various thiophenes and thiazoles with multiple derivatives.
Yield achieved ranged from 61% to 84% for different product variations.

Implication

Experimental development demonstrates effective cycloaddition to synthesize thiophenes and thiazoles.

Abstract

The [4+1] cycloaddition of enaminothiones and N-thioacylformamidines with various ylides has been developed. Various products of useful thiophenes and thiazoles were constructed in 61‒84% yields. Synthetic applications and primary explorations...

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a095bba7880e6d24efe1899 https://doi.org/10.1039/d6nj01052k

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Application of various ylides in the [4+1] cycloaddition of enaminothiones and N-thioacylformamidines for constructing substituted thiophenes and thiazoles

Key Points

Implication

Abstract

Discussion

Cite This Study

Application of various ylides in the [4+1] cycloaddition of enaminothiones and N-thioacylformamidines for constructing substituted thiophenes and thiazoles

Key Points

Implication

Abstract

Discussion

Cite This Study

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