Bidirectional Mendelian randomization analysis finds no causal association between PCOS and IgAN, suggesting further investigation is warranted.
Key Points
This study aims to explore the causal relationship between polycystic ovary syndrome (PCOS) and IgA nephropathy (IgAN) using Mendelian randomization methods.
Conducted bidirectional Mendelian randomization analysis using SNPs from two GWAS datasets for PCOS and IgAN.
Utilized inverse-variance weighted method and other sensitivity analyses.
Examined a total of 1424 PCOS cases versus 392,423 controls, and 15,587 IgAN cases versus 462,197 healthy controls.
No significant association found between PCOS and IgAN using FinnGen database SNPs (OR = 1.4405, 95% CI: 0.9907–2.0939, P = 0.05581).
PCOS summary statistics also showed no significant association with IgAN (OR = 1.1187, 95% CI: 0.5448–2.2972, P = 0.75988).
Reverse Mendelian randomization analysis indicated that IgAN does not increase the risk of PCOS (OR = 1.0473, 95% CI: 0.9871–1.1112, P = 0.1253).