Editorial discusses the effectiveness of treat-to-target urate-lowering therapy in primary care, suggesting improved outcomes.
We read with great interest the editorial by Singh¹ commenting on the study by Mulqueen et al² that showed similar rates of monosodium urate crystal dissolution in joints and tendons during treat-to-target (T2T) urate-lowering therapy (ULT). Dr. Singh eloquently articulates the compelling pathophysiological rationale for T2T: complete tophus resolution on dual-energy computed tomography within 12 months represents "an impressive notable finding" that is "uncommon or rare in chronic medical conditions."¹
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Therán-León et al. (2026) studied this question.
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