Substrate‑Driven Iridium Photocatalysts Enable Diastereoselective Dearomative Polyoxygenation of Hydroxyquinolines

Key Points

• The aim is to explore a substrate-driven strategy for diastereoselective dearomative polyoxygenation using iridium-based photocatalysts.
• Utilized a substrate-coordinated Ir(III) complex as a photocatalyst.
• Conducted reactions under visible light and ambient oxygen conditions.
• Focused on the polyoxygenation of 8-hydroxyquinolines.
• Achieved diastereoselective dearomative reactions with high selectivity.
• Demonstrated the efficacy of Ir(III) complexes in facilitating these reactions under mild conditions.
• Outlined a potential pathway for further applications in organic synthesis.