Monoterpene-indole alkaloid from Rinorea yaundensis and antidiabetic potential of its hydrochloride

Chromatographic resolutions of methanolic extract of the aerial parts of Rinorea yaundensis led to the isolation of a new monoterpene indole alkaloid yaundentine 1 , along with its previously reported hydrochloride 2 and sarpagine 3 , respectively. Moreover, compound 2 was screened to determine its possible antidiabetic properties via oral administration to streptozotocin-induced diabetic rats for 14 days. Their subsequent treatment with compound 2 significantly reduced the blood glucose levels in comparison with control glibenclamide. It could also be validated from the significant reduction in serum lipid profile markers and elevation in HDL-C, also signify the protective effect. The histopathological evaluation further revealed that the reduced number of islet cells were restored near to normal after treatment. This study revealed that compound 2 possesses a potential antidiabetic activity and this effect could be due to the multitarget mode of action, which enables its utility as a complementary drug for diabetes and associated complications.