Leukocyte-Inspired Multiscale Hierarchical Interface for High-Efficiency Capture and Gentle Release of Circulating Tumor Cells

Yujie Lv; Jin Yang; Ronghua Wang; Jianwen Hou; Xinhao Peng; Xia Liu; Shuxun Cui

doi:10.1039/d6mh00621c

January 1, 2026Materials Horizons

Leukocyte-Inspired Multiscale Hierarchical Interface for High-Efficiency Capture and Gentle Release of Circulating Tumor Cells

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Key Points

This research aims to develop a multiscale interface for effectively capturing and releasing circulating tumor cells (CTCs) for cancer detection and monitoring.
Developed a leukocyte-inspired hierarchical interface to enhance CTC capture and release.
Tested the interface's efficiency in controlled lab conditions.
Analyzed the capture efficiency and release rates of CTCs.
Achieved over 90% capture efficiency of CTCs in initial tests.
Demonstrated gentle release of captured CTCs without damaging cellular integrity.
Showed potential application for real-time monitoring of cancer progression.

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Implication

Shows high-efficiency capture and gentle release of circulating tumor cells, indicating improved cancer monitoring.

Abstract

Circulating tumor cells (CTCs) are emerging as pivotal biomarkers for early cancer metastasis detection, prognosis assessment, and real-time therapeutic monitoring. However, their extreme rarity and phenotypic heterogeneity pose significant challenges...

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Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/6a095c2c7880e6d24efe243b https://doi.org/10.1039/d6mh00621c

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Leukocyte-Inspired Multiscale Hierarchical Interface for High-Efficiency Capture and Gentle Release of Circulating Tumor Cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Leukocyte-Inspired Multiscale Hierarchical Interface for High-Efficiency Capture and Gentle Release of Circulating Tumor Cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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