Alzheimer disease is a progressive neurodegenerative disorder that involves the deteriorationof cognition and memory and is mainly caused by the older citizens. One of the most commonexamples of an acetylcholinesterase inhibitor, donepezil hydrochloride, has poor oralbioavailability because of a large proportion of first-pass metabolism and adversegastrointestinal events. The present study was carried out to formulate and evaluate Donepezilloaded mucoadhesive buccal films using the solvent casting method. Mucoadhesive buccalfilms were created by the solvent cast approach with different levels of polymers, plasticizers,and excipients. Six formulations (F1-F6) were formulated and tested in relation to the study ofphysicochemical characteristics such as the thickness, weight uniformity, folding endurance,surface pH, uniform drug content, mucoadhesive strength, and in-vitro drug release profile.The findings have shown that all formulations possessed acceptable physicochemical featuressuch as uniform distribution of drug content. Folding strength and mucoadhesive strength wereon the rise with polymer concentration which implies better mechanical strength and adhesion.The optimized formulation (F5) showed better drug release (92.8%), as compared to marketedformulation (75.9%), which showed better dissolution and possible better bioavailability.The formulation remained stable over a period of 6 months with no significant changes inphysicochemical properties, confirming its stability.
Pranav Jagtap (2026) studied this question.