What question did this study set out to answer?

To assess the ability of ruxolitinib to penetrate the blood brain barrier and its effect on cytokine storms in patients with haemophagocytic lymphohistiocytosis.

May 17, 2026Journal of Cellular and Molecular MedicineOpen Access

Ruxolitinib Penetrates Blood Brain Barrier and Reduces the Cytokine Storm in Patients With Haemophagocytic Lymphohistiocytosis

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Authors

WJWenjun JiNantong University KQKai QingShanghai Jiao Tong University JRJiayi RenRuijin Hospital

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Implication

Randomized trial evaluates ruxolitinib's effectiveness in reducing cytokine storms in patients with CNS involvement in HLH, suggesting novel therapeutic options.

Key Points

To assess the ability of ruxolitinib to penetrate the blood brain barrier and its effect on cytokine storms in patients with haemophagocytic lymphohistiocytosis.
Evaluated blood brain barrier permeability of ruxolitinib in 10 patients with secondary HLH, 2 having CNS involvement.
Documented ruxolitinib administration and monitored its clinical effects on cytokine levels.
Utilized a one-tailed test for assessing BBB penetration.
Ruxolitinib penetrated the blood brain barrier with permeability ranging from 5.31% to 18.08%.
In patients with CNS involvement, ruxolitinib demonstrated significant potential for reducing cytokine storms.
Findings support the recommended use of ruxolitinib in treating CNS-related HLH.

Cite This Study

Ji et al. (2026) studied this question.

synapsesocial.com/papers/6a095c5d7880e6d24efe27c3 https://doi.org/10.1111/jcmm.71173

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Implication

Randomized trial evaluates ruxolitinib's effectiveness in reducing cytokine storms in patients with CNS involvement in HLH, suggesting novel therapeutic options.

Ruxolitinib Penetrates Blood Brain Barrier and Reduces the Cytokine Storm in Patients With Haemophagocytic Lymphohistiocytosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Ruxolitinib Penetrates Blood Brain Barrier and Reduces the Cytokine Storm in Patients With Haemophagocytic Lymphohistiocytosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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