Key result
Stroke and bleeding risk scores show modest predictive accuracy in AF with advanced CKD.
Why the study?
The performance of clinical risk prediction scores for ischemic stroke and bleeding is not well established in patients with CKD and atrial fibrillation.
Do standard clinical risk prediction scores accurately predict ischemic stroke and intracranial bleeding in adults with atrial fibrillation across different levels of kidney function?
Cohort (n=134,560)
Yes
Do standard clinical risk prediction scores accurately predict ischemic stroke and intracranial bleeding in adults with atrial fibrillation across different levels of kidney function?
Standard clinical risk scores for stroke and bleeding have only modest predictive accuracy in patients with atrial fibrillation and chronic kidney disease, highlighting the need for better risk stratification tools in this population.
Stroke scores warrant cautious use in AF with CKD; leaves open validation of improved tools.
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Bansal et al. (2026) conducted a cohort in Atrial Fibrillation and Chronic Kidney Disease (n=134,560). Baseline estimated glomerular filtration rate (eGFR) was evaluated on Performance of risk scores for ischemic stroke and intracranial bleeding (c-statistics). Clinical risk prediction scores for stroke and bleeding showed modest predictive performance (lower c-statistics) among adults with atrial fibrillation and advanced chronic kidney disease.
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