Key result
Baseline heart rate and LVEDD predict LV recovery, occurring in ~46% of PPCM patients on bromocriptine.
Why the study?
The role of baseline right ventricular systolic function in left ventricular recovery remains poorly described in women with peripartum cardiomyopathy.
Does baseline right ventricular systolic function predict left ventricular recovery at six-months follow-up among women with peripartum cardiomyopathy?
Cohort (n=160)
Does baseline right ventricular systolic function predict left ventricular recovery at six-months follow-up among women with peripartum cardiomyopathy?
In women with peripartum cardiomyopathy in Uganda, under half achieved LV recovery at six months on GDMT and bromocriptine, with baseline heart rate and LVEDD predicting recovery.
Baseline HR and LVEDD may aid recovery risk stratification; leaves open RV function's predictive value and bromocriptine benefit.
Background: LV recovery in Peripartum Cardiomyopathy (PPCM) depends on several baseline factors including left ventricular ejection fraction (LVEF), LV end-diastolic diameter (LVEDD), duration of symptoms. The role baseline RV function in LV recovery remains poorly described. This study sought to determine the relationship between baseline RV systolic function and LV recovery at six-months follow up among women with PPCM in Uganda. Methods: Prospective cohort study of 80 PPCM cases and 80 healthy matched controls observed over a 6-month period while on goal-directed medical therapy (GDMT). All enrolled participants had a 12-lead electrocardiography, echocardiography at baseline and at 6-months follow-up for assessment of LV systolic function using LV global longitudinal strain (LV GLS) and LV EF whereas RV systolic function was assessed using; fractional area change (FAC), tricuspid annular plane excursion (TAPSE), RV lateral wall S' (RV S'), fractional wall strain (FWS) and RV global longitudinal strain (RV GLS). Results: The mean data of cases included age of 33.6 ± 6.6 years, LVEF 35.7 ± 11.0 %, LV GLS -11.9 ± 4.7 % and RV GLS -14.7 ± 10.9 %, RV FAC 32.9 ± 13.5 %, Lat S' 10.6 ± 3.0 cm/s and RV FWS -17.1 ± 7.2 %. LV recovery occurred among 46.3 % cases. Factors which predicted LV recovery included heart rate and LVEDD. Conclusion: Under half of PPCM cases had LV recovery at six-months on GDMT and Bromocriptine. Baseline heart rate and LVEDD predicted LV recovery.
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Nabbaale et al. (2025) conducted a cohort in Peripartum Cardiomyopathy (n=160). Goal-directed medical therapy (GDMT) and Bromocriptine vs. Healthy matched controls was evaluated on Left ventricular recovery. Baseline heart rate and LVEDD predicted left ventricular recovery, which occurred in 46.3% of women with peripartum cardiomyopathy at six months on GDMT and bromocriptine.
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