Why the study?
Although rare, myocarditis is a safety concern with mRNA COVID-19 vaccination, and the mechanisms behind these cases remain unexplained.
Residual double-strand RNA impurities in mRNA COVID-19 vaccines are hypothesized to be a potential trigger for vaccine-associated myocarditis.
No change to vaccination practice; hypothesis-generating for residual dsRNA as myocarditis trigger.
While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis.
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Milano et al. (2021) studied this question.
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