Synthetic study demonstrates copper-free fluorosulfonylation of arenediazonium salts, highlighting an efficient route to diverse arenesulfonyl fluorides.
Summary of main observation and conclusion The limited availability of highly valuable arenesulfonyl fluorides seriously hinders their further application in many research fields including medicinal chemistry and chemical biological, organic synthesis, polymer preparation, etc . We report herein a mild and efficient copper‐free Sandmeyer‐type fluorosulfonylation reaction of various arenediazonium salts to prepare valuable arenesulfonyl fluorides using K 2 S 2 O 5 as both a reductant and a practical sulfonyl source in combination with N ‐fluorobenzenesulfonimide as an effective fluorine source. This methodology provides an attractive route to diverse important arenesulfonyl fluorides given the overall practicality and scope.
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Lin et al. (2020) studied this question.
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