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February 21, 2007Proceedings of the National Academy of SciencesOpen Access

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer

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Authors

JHJunzo HamanishiMMMasaki MandaiMIMasashi Iwasaki

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Overview

Retrospective cohort study reveals that elevated PD-L1 and reduced CD8+ T cells independently predict poor prognosis in ovarian cancer, highlighting the PD-1 pathway as a therapeutic target.

Key Points

  • To assess whether tumor expression of PD-1 ligands and tumor-infiltrating CD8+ T lymphocytes serve as prognostic markers in human ovarian cancer.
  • Generated a novel antibody against PD-L1 compatible with paraffin-embedded human tissue specimens.
  • Analyzed tumor expression levels of PD-L1 and PD-L2 alongside intraepithelial CD8+ T lymphocyte counts in paraffin-embedded ovarian cancer samples.
  • Evaluated patient prognosis and independent risk factors using survival and multivariate statistical analyses.
  • High tumor PD-L1 expression correlated significantly with poorer patient survival, whereas elevated PD-L2 expression showed an adverse trend that did not reach statistical significance.
  • An inverse correlation was observed between tumor PD-L1 expression and the abundance of intraepithelial CD8+ T lymphocytes.
  • Multivariate analysis identified tumor PD-L1 expression and intraepithelial CD8+ T lymphocyte count as independent prognostic factors.

Cite This Study

Hamanishi et al. (2007) studied this question.

synapsesocial.com/papers/6a0982be00217ed3fb33f8b5https://doi.org/10.1073/pnas.0611533104
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