Key result
Calcium entry during the opening of a single L-type calcium channel in heart cells produces alterations in gating transition rates that evolve over hundreds of milliseconds.
The study demonstrates that calcium entry alters the gating transition rates of single L-type calcium channels in heart cells, revealing a mechanism for short-term channel modulation.
Hypothesis-generating for calcium-dependent L-type channel modulation; leaves open relevance to human arrhythmias or therapy.
Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and neurotransmitters. Here evidence for the control of gating by calcium was found in electrophysiological records of single, L-type calcium channels in heart cells. Conditional open probability analysis revealed that calcium entry during the opening of a single channel produces alterations in gating transition rates that evolve over the course of hundreds of milliseconds. Such alteration of calcium-channel gating by entry of a favored permeant ion provides a mechanism for the short-term modulation of single-ion channels.
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Yue et al. (1990) studied L-type calcium channels in heart cells. Calcium entry was evaluated on Alterations in gating transition rates. Calcium entry during the opening of a single L-type calcium channel in heart cells produces alterations in gating transition rates that evolve over hundreds of milliseconds.
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