[reaction: see text] The origin of exclusive exo-stereochemistry in the alkylation of Meyers-type enolate 2 has been studied. It was found that the intramolecular complex with a strong Li...O(ring) interaction (the O-complex) may be responsible as the major enolate species in tetrahydrofuran (THF). The transition state of the O-complex leading to exo-stereochemistry is found to be the most favorable process in THF.
No takes yet. Share an insight, caveat, or question.
Ikuta et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: