Key result
Paroxetine shows no difference in hip fracture risk versus other SSRIs in elderly nursing home residents.
Why the study?
Does paroxetine increase the risk of hip fractures compared to other SSRIs in depressed elderly nursing home residents?
Cohort
Does paroxetine increase the risk of hip fractures compared to other SSRIs in depressed elderly nursing home residents?
Paroxetine does not appear to carry a differential risk of hip fractures compared to other SSRIs in elderly nursing home residents with depression.
Observational data show no significant difference in hip fracture risk with paroxetine; leaves open whether choice among SSRIs affects outcomes in elderly nursing home residents.
AIM: To evaluate comparative safety of paroxetine and other selective serotonin reuptake inhibitors (SSRIs) for the risk of hip fractures. PATIENTS & METHODS: A propensity score-matched retrospective cohort study was conducted using 2007-2010 Minimum Data Set linked Medicare data. Robust Cox proportional hazards model was used to evaluate the risk of hip fractures in depressed elderly nursing home residents. RESULTS: Cox analysis did not find any significant difference in the risk of hip fractures for the paroxetine users (hazard ratio: 1.09; 95% CI: 0.91-1.32) when compared with other SSRIs. Results from the sensitivity analysis supported the main findings. CONCLUSION: There was no differential risk of hip fractures between paroxetine and other SSRIs. Future studies are needed to evaluate other anticholinergic effects of paroxetine.
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Bali et al. (2016) conducted a cohort in Depression. Paroxetine vs. Other selective serotonin reuptake inhibitors (SSRIs) was evaluated on Risk of hip fractures (HR 1.09, 95% CI 0.91-1.32). Paroxetine use in depressed elderly nursing home residents was not associated with a significantly different risk of hip fractures compared with other SSRIs (HR 1.09; 95% CI 0.91-1.32).
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