Key result
Combination treatment with acetazolamide and hydrochlorothiazide increased urine output by greater than 2-fold compared to acetazolamide alone in rats (p<0.001).
Why the study?
Does the combination of acetazolamide and hydrochlorothiazide increase diuresis in rats compared to either agent alone?
Does the combination of acetazolamide and hydrochlorothiazide increase diuresis in rats compared to either agent alone?
Effect estimate: >2 fold increase
p-value: p=<0.001
The combination of acetazolamide and hydrochlorothiazide produces massive diuresis in rats by down-regulating pendrin and inhibiting NCC, suggesting a potent diuretic regimen.
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Hypothesis-generating in rats; leaves open clinical translation or human trials.
Zahedi et al. (2013) studied this question. Acetazolamide (ACTZ) plus Hydrochlorothiazide (HCTZ) vs. Acetazolamide (ACTZ) alone was evaluated on Urine output (>2 fold increase, p=<0.001). Combination treatment with acetazolamide and hydrochlorothiazide increased urine output by greater than 2-fold compared to acetazolamide alone in rats (p<0.001).
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